Fig 5.TIF (2.64 MB)
Effects of fenretinide (4-HPR) on Wnt3a/β-catenin pathway.
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posted on 2016-07-01, 17:51 authored by Barbara Bassani, Desirèe Bartolini, Arianna Pagani, Elisa Principi, Massimo Zollo, Douglas M. Noonan, Adriana Albini, Antonino BrunoWB analysis for proteins involved in Wnt3a/β-catenin pathway show decreased level of Wnt3a in DAOY cells (A) treated for 24 hours with 4-HPR at the highest dose while Wnt3a down-regulation started at 2.5 μM in ONS-76 cells (B). Axin-1 and pGSK3β decreased in DAOY and ONS-76 cells treated as above (C-F). Decreased levels of β-catenin was observed at 6 and 24 hours following 4-HPR treatment in DAOY and ONS-76 cells (G, H).
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PARPMedulloblastoma Cell Spheroids MedulloblastomaMB cell migrationWestern Blot analysis4- HPR treatment4- HPR targetswell-tolerated cancer chemopreventiveMB tumor cell growthcell cycle arrestONS -76 cells4- HPR inductionall-trans retinoic acidWnt 3a PathwayDAOYONS -76 spheroid formationSox -2 gene expressionROSoxygen reactive speciescell cycle effectsBTICABCGMB cell linesβ- cateninPCRflow cytometry analysissurface markers CD 133childhood brain malignancyERKBITIC4- HPRMB spheroids model4- HPR ability
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