Effects of exercise and lifestyle intervention on oxidative stress in chronic kidney disease

<p><b>Objectives:</b> Determine the effects of a 12-month exercise and lifestyle intervention program on changes in plasma biomarkers of oxidative stress in pre-dialysis chronic kidney disease (CKD) patients.</p> <p><b>Methods:</b> A total of 136 stage 3–4 CKD patients were randomized to receive standard nephrological care with (<i>N</i> = 72) or without (<i>N</i> = 64) a lifestyle and exercise intervention for 12 months. Plasma total F<sub>2</sub>-isoprostanes (IsoP), glutathione peroxidase (GPX) activity, total antioxidant capacity (TAC), anthropometric and biochemical data were collected at baseline and at 12 months.</p> <p><b>Results:</b> There were no significant differences between groups at baseline. There were no significant differences in changes for standard care and lifestyle intervention, respectively, in IsoP (<i>p</i> = 0.88), GPX (<i>p</i> = 0.87), or TAC (<i>p</i> = 0.56). Patients identified as having high IsoP at baseline (>250 pg/mL) had a greater decrease in IsoP with lifestyle intervention compared to standard care; however, the difference was not statistically significant (<i>p</i> = 0.06). There was no difference in the change in kidney function (eGFR) between standard care and lifestyle intervention (<i>p</i> = 0.33).</p> <p><b>Discussion:</b> Exercise and lifestyle modification in stage 3–4 CKD did not produce changes in systemic biomarkers of oxidative stress over a 12-month period, but patients with high IsoP may benefit most from the addition of intervention to standard care.</p>