Effects of adding inhibitory synaptic input.

<p><b>(A)</b> shows the effect of increasing <i>I</i><sub>ratio</sub> to 0.5 from 0 on the ISI distributions generated by the HH model at 2.3 and 9 spikes/s (<i>R</i><sub>epsc</sub> was adjusted to 694 and 1304 Hz to achieve firing rates of 2.3 and 9 spikes). Model distributions (pink; <i>I</i><sub>ratio</sub> = 0.5, <i>g</i><sub>BK</sub> = 1) are superimposed on ISI distributions from the reference data in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180368#pone.0180368.g001" target="_blank">Fig 1</a> (blue). Increasing <i>I</i><sub>ratio</sub> increases the number of short ISIs, and the model ISI distribution no longer matches the reference data. <b>(B)</b> shows the effect of increasing <i>g</i><sub>BK</sub> to 3.2 mS/cm<sup>2</sup>, with <i>R</i><sub>epsc</sub> adjusted to 694 and 1290 Hz to achieve firing rates of 2.3 and 9 spikes/s. ISI distributions from the adjusted model (purple; <i>I</i><sub>ratio</sub> = 0.5, <i>g</i><sub>BK</sub> = 3.2) are superimposed on ISI distributions from the reference data in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180368#pone.0180368.g001" target="_blank">Fig 1</a> (blue). By increasing <i>g</i><sub>BK</sub>, a good fit can again be obtained. <b>(C)</b> shows the ‘average spike waveform’ for three different runs of the model–<i>I</i><sub>ratio</sub> = 0 in green (from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0180368#pone.0180368.g006" target="_blank">Fig 6B</a>), <i>I</i><sub>ratio</sub> = 0.5, <i>g</i><sub>BK</sub> = 1 in pink, and <i>I</i><sub>ratio</sub> = 0.5, <i>g</i><sub>BK</sub> = 3.2 in purple. Increasing <i>I</i><sub><i>ratio</i></sub> results in an attenuation of the observed HAP, which can be reversed by increasing <i>g</i><sub>BK</sub>, restoring a good fit to the <i>in vivo</i> reference data.</p>