Effects of Ganoderma, Rhodiola and grape seed extracts on the glucuronidation and oral bioavailability of resveratrol in rats

<p>Herb extracts were shown to inhibit the activity of UDP-glucuronosyltransferases (UGTs) <i>in vitro</i>. However, the actual <i>in vivo</i> effect of the inhibitory ability on oral bioavailability is yet verified. In this study, resveratrol (RES) was used as a model drug to study the effect of three Chinese herb extracts, Ganoderma, Rhodiola and grape seed, on the <i>in vitro</i> and <i>in vivo</i> inhibition of glucuronidation and the <i>in vivo</i> bioavailability of RES. Overall, although herb extracts might show inhibition on glucuronidation of RES <i>in vitro</i> and <i>in vivo</i>, the inhibition of glucuronidation did not necessarily mean to improve the <i>in vivo</i> bioavailability of RES.</p>