Effects of ACO on sodium currents in Guinea-pig ventricular myocytes.

<p>(A) Representative traces of the peak I<sub>Na</sub> recorded in a Guinea-pig ventricular myocyte prior to and after 3 μM ACO. (B) The I-V curves showing the current densities of peak I<sub>Na</sub>. n = 5. (C) The SS-inactivation and -activation curves. n = 5. (D) The I-V curves of the voltage-gated I<sub>NaL</sub> densities. n = 5. (E) Representative traces of voltage-dependent I<sub>NaL</sub> recorded in a Guinea-pig ventricular myocyte prior to and post 3μM ACO. *<i>p</i> < 0.05, <sup>†</sup><i>p</i> < 0.01, vs. baseline.</p>