Effect of testosterone therapy on the female voice

2016-02-09T10:31:02Z (GMT) by R. Glaser A. York C. Dimitrakakis
<p><b>Objectives</b> This prospective study was designed to investigate the effect of testosterone, delivered by subcutaneous implants, on the female voice.</p> <p><b>Methods</b> Ten women who had opted for testosterone therapy were recruited for voice analysis. Voices were recorded prior to treatment and at 3 months, 6 months, and 12 months while on testosterone therapy. Acoustic samples were collected with subjects reading a sentence, reading a paragraph, and participating in a conversation. Significant changes in the voice over time were investigated using a repeated-measures analysis of variance with the fundamental frequency (<i>F</i><sub>0</sub>) as a response variable. Demographic variables associated with characteristics of the voice were assessed.</p> <p><b>Results</b> There were no significant differences in average <i>F</i><sub>0</sub> related to smoking history, menopausal status, weight, or body mass index. There was no difference in average fundamental speaking frequency (sentence, paragraph, conversation) between the pre-treatment group and any post-treatment group at 3 and 12 months. There was an increase in sentence speech <i>F</i><sub>0</sub> at 6 months. Two of three patients with lower than expected <i>F</i><sub>0</sub> at baseline improved on testosterone therapy.</p> <p><b>Conclusion</b> Therapeutic levels of testosterone, delivered by subcutaneous implant, had no adverse affect on the female voice including lowering or deepening of the voice.</p>