Fig 6.TIF (1.49 MB)
Effect of genipin on KSHV infection.
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posted on 2016-10-13, 17:34 authored by Miyeon Cho, Seok Won Jung, Soomin Lee, Kuwon Son, Gyu Hwan Park, Jong-Wha Jung, Yu Su Shin, Taegun Seo, Hyosun Cho, Hyojeung KangEffects of genipin on KSHV infection to iSLK-puro cells were determined by KSHV infection assay. (A) GFP foci formed on 72 μM genipin treated iSLK-puro cells that were infected for 72 h with KSHV virions (low titer) harvested from iSLK-BAC16 cells treated with only sodium butyrate. (B) A graph showing the effect of genipin treatment at 72 μM on the low titer KSHV infection to iSLK-puro cells. (C) GFP foci formed on 72 μM genipin treated iSLK-puro cells that were infected for 72 h with KSHV virions (high titer) harvested from iSLK-BAC16 cells treated with both sodium butyrate and doxycyclin. (D) A graph showing the effect of genipin treatment at 72 μM on the high titer KSHV infection to iSLK-puro cells.
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KSHV intracellular copy numbersKSHV life cyclechromosomes protein 3KSHV lytic replicationCTCFRNARTAgenipin treatmentKSHV extracellular copy numbersDNMTKSHV LANA transcriptsKSHV infectionAIDSSMCDNAconcentration72.5 μ MiSLK-BAC 16 KSHV infection systemKSHV latency control region49.5 μ Mchromatin immunoprecipitation assayiSLK-BAC 16 cells
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