pone.0202354.g003.tif (233.2 kB)
Effect of endothelium removal and CaSR inhibition on vascular response to R-568.
figure
posted on 2018-08-09, 17:58 authored by Natalia Di Pietro, Maria Assunta Potenza, Sara Di Silvestre, Francesco Addabbo, Nadia Di Pietrantonio, Pamela Di Tomo, Caterina Pipino, Domitilla Mandatori, Carola Palmerini, Paola Failli, Mario Bonomini, Monica Montagnani, Assunta Pandolfi(A) MVB isolated from 8-week old WKY (closed symbols) and SHR (open symbols) were stimulated with increasing concentrations of R-568 in the presence (circles) or in the absence (squares) of endothelium. Results shown are the mean ± SEM of 3 (WKY) and 3 (SHR) independent experiments. Data from each curve were normalized as in Fig 1. (B) MVB isolated from 8-week old WKY (closed symbols) and SHR (open symbols) were stimulated with increasing concentrations of R-568 in the absence (circles) or after pretreatment with (diamonds) Calhex-231 (3 μM/20 min). Results are the mean ± SEM of 3 WKY and 3 SHR independent experiments. Data from each curve were normalized as in Fig 1. *p < 0.05 vs respective CTRL curve.
