ol6b03118_si_003.cif (832.01 kB)
Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives
dataset
posted on 2016-12-07, 18:54 authored by Shawn
D. Nelson, Mathias J. Wawer, Stuart L. SchreiberSp3-rich compounds are underrepresented in libraries
for probe- and drug-discovery, despite their promise of extending
the range of accessible molecular shapes beyond planar geometries.
With this in mind, a collection of single-enantiomer bicyclic, fused
cyclopentenones underpinned by a complexity-generating Pauson–Khand
cyclization was synthesized. A fingerprint of biological actions of
these compounds was determined immediately after synthesis using real-time
annotation−a process relying on multiplexed measurements of
alterations in cell morphological features.