Table 2.xls (5.5 kB)
Distribution of TMEM173/STING HAQ and R232H in patients and healthy controls from Netherlands cohort.
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posted on 2018-01-03, 18:40 authored by Juan S. Ruiz-Moreno, Lutz Hamann, Javeed A. Shah, Annelies Verbon, Frank P. Mockenhaupt, Monika Puzianowska-Kuznicka, Jan Naujoks, Leif E. Sander, Martin Witzenrath, John C. Cambier, Norbert Suttorp, Ralf R. Schumann, Lei Jin, Thomas R. Hawn, Bastian OpitzDistribution of TMEM173/STING HAQ and R232H in patients and healthy controls from Netherlands cohort.
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R 232H attenuated cytokine productionsusceptibilitySTING-deficient murine macrophagesR 232H allelescyclic GMP-AMP synthaseSTING-deficient animalscyclic dinucleotidesTMEMIFNprotozoal infectionsRecent studiesHAQ STING variant impairs cGAS-dependentcGAS-STING cascadeLegionnairehaplotype frequencyDNATrial registration ClinicalTrials.gov DRKS 00005274CDNmouse modelwild-type miceLegionella pneumophilaresponsepro-inflammatory cytokines
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