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Discovery of New Tetracyclic Tetrahydrofuran Derivatives as Potential Broad-Spectrum Psychotropic Agents
journal contribution
posted on 2005-03-24, 00:00 authored by Javier Fernández, José M. Alonso, José I. Andrés, José M. Cid, Adolfo Díaz, Laura Iturrino, Pilar Gil, Anton Megens, Victor K. Sipido, Andrés A. TrabancoA series of novel tetracyclic tetrahydrofuran derivatives was prepared and evaluated for its potential psychotropic properties. In vitro affinities for multiple dopaminergic, serotonergic, α-adrenergic, and histamine receptors and
for the norepinephrine transporter as well as the ED50 values
obtained in some in vivo assays for antipsychotic, anxiolytic,
and antidepressant potential are reported. Compounds (−)-1,
(−)-8d, and (+)-8d have been identified as potential broad-spectrum psychotropic agents.
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serotonergicPsychotropicseriesnorepinephrine transporteragentPotentialantidepressantpsychotropic propertiesdopaminergicvivo assaysaffinityNew Tetracyclic Tetrahydrofuran DerivativesCompoundadrenergicnovel tetracyclic tetrahydrofuran derivativesanxiolyticantipsychoticED 50 valueshistamine receptorsAgent
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