ol7b02516_si_001.pdf (5.15 MB)
Direct Synthesis of Acyl Fluorides from Carboxylic Acids with the Bench-Stable Solid Reagent (Me4N)SCF3
journal contribution
posted on 2017-10-12, 19:48 authored by Thomas Scattolin, Kristina Deckers, Franziska SchoenebeckA convenient, highly
efficient, and selective transformation of
aliphatic and aromatic carboxylic acids to acyl fluorides is reported.
In contrast to established approaches that require toxic or volatile
additives and base and reaction control (i.e., cooling, slow addition),
this protocol allows for a straightforward access to various R-COF
entities upon direct reaction with the bench-stable, solid reagent
(Me4N)SCF3 at room temperature. The method is
base- and additive-free, compatible with late-stage synthetic applications,
high functional group tolerance, and facile target compound purification
via filtration.
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entityaliphaticBench-Stablecarboxylic acidsacyl fluoridesaccessadditiveapplicationCarboxylic Acidscoolingtarget compound purificationReagentroom temperatureadditive-freeapproachtransformationcontrastreaction controlbench-stablereagentfiltrationi.eAcyl FluoridesR-COF entitiesgroup tolerancemethodDirect Synthesislate-stage
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