Diorganotin(IV) complexes of 2-chloridophenylacetohydroxamic acid as prospective antimicrobials: synthesis, characterization, and biological properties
New diorganotin(IV) complexes [Me2Sn(2-ClC6H4CH2CONHO)2] (1) and [n-Bu2Sn(2-ClC6H4CH2CONHO)2] (2) have been synthesized by reactions of Me2SnCl2 and n-Bu2SnCl2 with potassium 2-chloridophenylacetohydroxamate (2-ClPhAHK = 2-ClC6H4CH2CONHOK) in 1:2 molar ratio in MeOH+C6H6 solvent medium and characterized by elemental analyses, molar conductivity, molecular weight determinations and spectroscopic techniques (IR, 1H, 13C, and 119Sn NMR) and mass spectrometry. Bonding through carbonyl and hydroxamic oxygens (O,O coordination) and distorted-octahedral geometry around tin is proposed. The electrochemical behavior of 1 and 2 studied by cyclic voltammetry shows quasi-reversible reductions. Thermal behavior of 1 and 2 in N2 shows decomposition in one step affording SnO as the residue. The in vitro antimicrobial activity assay against pathogenic Gram-negative bacteria viz. Salmonella typhi, Escherichia coli; Gram-positive Bacillus cereus and Staphylococcus aureus and fungi Aspergillus niger and Alternaria alternata by MIC method revealed their significant antimicrobial potential relative to the respective standard Chloramphenicol and Nystatin drugs.
