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Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells

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posted on 2016-01-22, 00:00 authored by Jing Xu, Jing Kang, Xiaocong Sun, Xiangrong Cao, Kasimu Rena, Dongho Lee, Quanhui Ren, Shen Li, Yasushi Ohizumi, Yuanqiang Guo
A bioassay-guided phytochemical investigation of the leaves of Casearia balansae led to the isolation of six new cucurbitane-type triterpenoid derivatives (balanterpenes A–F, 16) and four new clerdoane-type diterpenoids (balanterpenes G–J, 710). The structures of 110 were established on the basis of extensive analysis of NMR spectroscopic data, X-ray crystallography, and experimental and calculated electronic circular dichroism spectra. Compound 1 features a ring-expanded triterpenoid skeleton with the C-19 methyl involved in the ring formation, compound 6 possesses a rare hexanortriterpenoid scaffold, and compounds 710 may be four new diterpenoid artifacts presumably formed during the extraction and purification processes. Compounds 3 and 710 showed promoting effects on neurite outgrowth of PC12 cells with EC50 values in the range 2.9–10.0 μM.

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