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Di- and Triterpenoids from the Leaves of Casearia balansae and Neurite Outgrowth Promoting Effects of PC12 Cells
dataset
posted on 2016-01-22, 00:00 authored by Jing Xu, Jing Kang, Xiaocong Sun, Xiangrong Cao, Kasimu Rena, Dongho Lee, Quanhui Ren, Shen Li, Yasushi Ohizumi, Yuanqiang GuoA bioassay-guided phytochemical investigation
of the leaves of Casearia balansae led to the isolation
of six new cucurbitane-type triterpenoid derivatives (balanterpenes
A–F, 1–6) and four new clerdoane-type
diterpenoids (balanterpenes G–J, 7–10). The structures of 1–10 were established on the basis of extensive analysis of NMR spectroscopic
data, X-ray crystallography, and experimental and calculated electronic
circular dichroism spectra. Compound 1 features a ring-expanded
triterpenoid skeleton with the C-19 methyl involved in the ring formation,
compound 6 possesses a rare hexanortriterpenoid scaffold,
and compounds 7–10 may be four new
diterpenoid artifacts presumably formed during the extraction and
purification processes. Compounds 3 and 7–10 showed promoting effects on neurite outgrowth
of PC12 cells with EC50 values in the range 2.9–10.0
μM.
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skeletonderivativemethylbalanterpeneLeavecompoundPC 12 cellscrystallographyscaffoldinvestigationCasearia balansaeformationoutgrowthCellsAneuritehexanortriterpenoidbasisextractiontriterpenoidartifactNeurite Outgrowth Promoting EffectsisolationphytochemicalNMR spectroscopic dataDiTriterpenoiddichroismCompound 1 featuresditerpenoidEC 50 valuesspectraanalysispurification
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