Development of a CONSORT Extension for adaptive clinical trials

Dimairo, Munya; Todd, Susan; Julious, Steven; Jaki, Thomas; Wason, James; Hind, Daniel; Mander, Adrian; Weir, Christopher; Koenig, Franz; Altman, Doug; Nicholl, Jon; Hamasaki, Toshimitsu; Proschan, Michael; Scott, John; Walton, Marc; Ando, Yuki; Biggs, Katie; Pallmann, Philip; Coates, Elizabeth

doi:10.15131/shef.data.5331469.v1

ACE Project Protocol v2.3.pdf (334.54 kB)

Development of a CONSORT Extension for adaptive clinical trials

journal contribution

posted on 2017-12-08, 16:43 authored by Munya Dimairo, Susan Todd, Steven Julious, Thomas Jaki, James Wason, Daniel Hind, Adrian Mander, Christopher Weir, Franz Koenig, Doug Altman, Jon Nicholl, Toshimitsu Hamasaki, Michael Proschan, John Scott, Marc Walton, Yuki Ando, Katie Biggs, Philip Pallmann, Elizabeth Coates

The ACE Project aims to develop a consensus-driven reporting guidance tailored for ADs in the form of a CONSORT extension. We hope this will enhance transparency, credibility, reproducibility, and replicability of adaptive trials. The hope would be to facilitate uptake of ADs in clinical trials research when appropriate.

The ACE Project is jointly funded by the NIHR and MRC HTMR, and is led by a multidisciplinary Steering Working Group of international experts in collaboration with the CONSORT Executive Group and the MRC HTMR Adaptive Designs Working Group