ol6b01516_si_002.cif (508.74 kB)
Detrifluoroacetylative in Situ Generation of Free 3‑Fluoroindolin-2-one-Derived Tertiary Enolates: Design, Synthesis, and Assessment of Reactivity toward Asymmetric Mannich Reactions
dataset
posted on 2016-06-15, 17:54 authored by Chen Xie, Lijun Zhang, Wanxing Sha, Vadim
A. Soloshonok, Jianlin Han, Yi PanThe discovery of
detrifluoroacetylative in situ generation of a
new type of fluorinated amide enolates derived from 3-fluoroindolin-2-one
and their asymmetric Mannich additions with sulfinylaldimines bearing
fluoroalkyl groups is reported, which afforded α-fluoro-β-(fluoroalkyl)-β-aminoindolin-2-ones
containing C–F quaternary stereogenic centers with excellent
yields and high diastereoselectivities.