Detrifluoroacetylative in Situ Generation of Free 3‑Fluoroindolin-2-one-Derived Tertiary Enolates: Design, Synthesis, and Assessment of Reactivity toward Asymmetric Mannich Reactions
datasetposted on 15.06.2016 by Chen Xie, Lijun Zhang, Wanxing Sha, Vadim A. Soloshonok, Jianlin Han, Yi Pan
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
The discovery of detrifluoroacetylative in situ generation of a new type of fluorinated amide enolates derived from 3-fluoroindolin-2-one and their asymmetric Mannich additions with sulfinylaldimines bearing fluoroalkyl groups is reported, which afforded α-fluoro-β-(fluoroalkyl)-β-aminoindolin-2-ones containing C–F quaternary stereogenic centers with excellent yields and high diastereoselectivities.