Design of fragment-derived, covalent inhibitors of SARS-CoV-2 main protease

This study discusses two potential inhibitors of SARS-CoV-2 main protease, in which warheads (aldehyde and nitrile) capable of reversible covalent bond formation to the catalytic cysteine, are linked to a fragment-derived inhibitor. The PDF file for to the article and the PDB format structure file with the proposed binding modes are provided.