jm0155897_si_001.pdf (587.25 kB)
Design, Synthesis, and Evaluation of Opioid Analogues with Non-Peptidic β-Turn Scaffold: Enkephalin and Endomorphin Mimetics
journal contribution
posted on 2002-03-03, 00:00 authored by Masakatsu Eguchi, Richard Y. W. Shen, J. Paul Shea, Min S. Lee, Michael KahnWe have identified a μ-selective opioid receptor
agonist without a cationic amino group in the molecule from
libraries of bicyclic β-turn peptidomimetics. The biologically
active conformation of the lead is proposed to mimic an
endomorphin type III 4 → 1 β-turn conformation.