ja4062294_si_002.pdf (383.28 kB)
Design Space for Complex DNA Structures
journal contribution
posted on 2013-12-04, 00:00 authored by Bryan Wei, Mingjie Dai, Cameron Myhrvold, Yonggang Ke, Ralf Jungmann, Peng YinNucleic
acids have emerged as effective materials for assembling
complex nanoscale structures. To tailor the structures to function
optimally for particular applications, a broad structural design space
is desired. Despite the many discrete and extended structures demonstrated
in the past few decades, the design space remains to be fully explored.
In particular, the complex finite-sized structures produced to date
have been typically based on a small number of structural motifs.
Here, we perform a comprehensive study of the design space for complex
DNA structures, using more than 30 distinct motifs derived from single-stranded
tiles. These motifs self-assemble to form structures with diverse
strand weaving patterns and specific geometric properties, such as
curvature and twist. We performed a systematic study to control and
characterize the curvature of the structures, and constructed a flat
structure with a corrugated strand pattern. The work here reveals
the broadness of the design space for complex DNA nanostructures.