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Denigrins A–C: new antitubercular 3,4-diarylpyrrole alkaloids from Dendrilla nigra

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Version 2 2014-05-09, 09:16
Version 1 2014-05-09, 09:16
journal contribution
posted on 2014-05-09, 09:16 authored by Muthyala Murali Krishna Kumar, Jarpula Devilal Naik, Kancherla Satyavathi, Hechhu Ramana, Pemmadi Raghuveer Varma, Kurre Purna Nagasree, Desaraju Smitha, Desaraju Venkata Rao

Chemical diversity is vital to antitubercular drug discovery as it ensures a novel bioactivity profile. Marine sponges have so far provided more than 1000 new bioactive molecules. Ethyl acetate extract of the marine sponge Dendrilla nigra on bioactivity-guided screening yielded three new compounds denigrins A–C, with potent antitubercular activity. Spectral and chemical analyses confirmed that these three compounds belong to the 3,4-diaryl pyrrole alkaloid category. The presence of monohydroxy substitution on benzene rings is not very common in lamellarin and related 3,4-diaryl pyrrole alkaloids isolated from marine invertebrates. Among these, denigrin C showed highest potency (minimum inhibitory concentration 4 μg/mL) against Mycobacterium tuberculosis H37Rv.

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