Deciphering the Origin of Stereoinduction in Cooperative Asymmetric Catalysis Involving Pd(II) and a Chiral Brønsted Acid

2015-06-19T00:00:00Z (GMT) by Garima Jindal Raghavan B. Sunoj
The density functional (M06) computations on a cooperative multicatalytic reaction involving palladium acetate and a chiral Brønsted acid in the conversion of an indenyl cyclobutanol to spirocyclic indene bearing a quaternary carbon ring junction are reported. A chiral Pd-<i>bis</i>-phosphate is identified as the active catalyst in the enantioselective ring expansion as compared to alternative possibilities wherein the chiral phosphate/phosphoric acid is in the outer sphere of palladium. The enantiocontrolling transition state exhibited more effective C–H···π interactions, lower distortion of the catalyst, and an orthogonal orientation of the bulky phosphate ligands.