ol5b02403_si_004.cif (2.2 MB)
Dearomative Indole Bisfunctionalization via a Diastereoselective Palladium-Catalyzed Arylcyanation
dataset
posted on 2015-10-02, 00:00 authored by David
A. Petrone, Andy Yen, Nicolas Zeidan, Mark LautensThe first Pd-catalyzed
dearomative indole bisfunctionalization
via a diastereoselective arylcyanation is reported. This method facilitates
the formation of diverse indoline scaffolds bearing congested stereocenters
with high levels of diastereoselectivity. This also represents the
first example of a cyanation mechanism involving a 2° benzylic
Pd(II) intermediate.