De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds

Jaganmohan, Chikkanti; P., Vinay Kumar K.; G., Sandeep Reddy; Mohanty, Sandeep; Kumar, Jaydeep; B., Venkateswara Rao; Tadiparthi, Krishnaji; Raghunadh, Akula

doi:10.6084/m9.figshare.5734758

lsyc_a_1391291_sm6670.docx (1.4 MB)

De novo synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazolin-4(1H)-one compounds

journal contribution

posted on 2017-12-27, 07:00 authored by Chikkanti Jaganmohan, Vinay Kumar K. P., Sandeep Reddy G., Sandeep Mohanty, Jaydeep Kumar, Venkateswara Rao B., Krishnaji Tadiparthi, Akula Raghunadh

A new versatile and efficient strategy for the synthesis of 2,2-bis(dimethylamino)-3-alkyl or benzyl 2,3-dihydroquinazoline-4(1H)-one compounds has been developed by one-pot multicomponent reaction with isatoic anhydride, amines followed by in situ-generated Vilsmeier reagent. The reaction has also been studied with different amines and solvents.