code_files.zip (48.77 kB)
Dataset for: A regulated multiscale closed-loop cardiovascular model, with applications to hemorrhage and hypertension
dataset
posted on 2018-04-20, 02:57 authored by Daniel Joseph Canuto, Kwitae Chong, Cayley Bowles, Erik P. Dutson, Jeff D. Eldredge, Peyman BenharashA computational tool is developed for simulating the dynamic response of the human cardiovascular system to various stressors and injuries. The tool couples zero-dimensional models of the heart, pulmonary vasculature, and peripheral vasculature to one-dimensional models of the major systemic arteries. To simulate autonomic response, this multiscale circulatory model is integrated with a feedback model of the baroreflex, allowing control of heart rate, cardiac contractility, and peripheral impedance. The performance of the tool is demonstrated in two scenarios: neurogenic hypertension by sustained stimulation of the sympathetic nervous system, and an acute 10 percent hemorrhage from the left femoral artery.