figshare
Browse
ppat.1007323.g004.tif (459.52 kB)

DY, 139H, and ME7H have similar PMCA conversion coefficients.

Download (459.52 kB)
figure
posted on 2018-10-18, 18:08 authored by Thomas E. Eckland, Ronald A. Shikiya, Jason C. Bartz

Western blot (A) detection of PrPSc from PK digested PMCA reactions seeded with serial dilutions of either DY, 139H or ME7H-infected brain homogenate after one round of PMCA. The PMCA-CC of DY, 139H, or ME7H seeded reactions (B) did not significantly (p>0.05) differ. This experiment was repeated a minimum of three times with similar results.

History

Usage metrics

    PLOS Pathogens

    Categories

    Keywords

    prion conversion efficiencylong-incubation period strainsPrion strain interference influences prion strain dynamicsshort-incubation period strainPrP Cprion strainsstrain interferenceprotein misfolding cyclic amplification strain interferenceconversion efficiency prion strains Prion diseasesImportantly PMCA reactionsanimal bioassay studieslong-incubation period strainPrP Sc

    Licence

    CC BY 4.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC