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DNA Binding, amelioration of oxidative stress, and molecular docking study of Zn(II) metal complex of a new Schiff base ligand

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Version 2 2018-05-29, 05:53
Version 1 2018-05-17, 07:13
journal contribution
posted on 2018-05-29, 05:53 authored by Dipu Kumar Mishra, Uttam Kumar Singha, Ananya Das, Somit Dutta, Pallab Kar, Arnab Chakraborty, Arnab Sen, Biswajit Sinha

A new Schiff base ligand, H2L, and its Zn(II) complex were prepared and characterized by different analytical and spectroscopic techniques. The elemental analysis results suggest the stoichiometry of the complex to be 1:1. The molar conductance study shows the non-electrolytic nature of the complex. Infrared spectra reveal that the metal ion is coordinated in tetradentate fashion which was further confirmed by NMR study. The synthesized complex was found to interact with CT-DNA quite efficiently. The DNA binding study of the complex was explored by UV–vis and viscosity measurement. Fluorescence titration studies and the experimental results suggest that the complex might bind to DNA via an intercalative mode. The in silico target prediction and molecular docking experiments confirm that, apart from high interaction potentiality with nucleotides, the complex has possible implications in carcinogenesis, too.

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