DEVELOPMENT OF STEREOSELECTIVE SYNTHESES OF BROMODOMAIN INHIBITORS AS ANTI-CANCER DRUGS

2018-04-16T00:05:31Z (GMT) by MOHAMMAD AL AMIN
This project explored the design, synthesis and testing of small molecules as anticancer agents. The compounds sought to block a particular family of (BET domain) proteins that affect cell growth. Specifically the research explored novel chemical scaffolds and required techniques to either synthesise or separate chiral substances. Encouragingly, these molecules were found to successfully block transcription pathways and represent an exciting new class of anticancer drugs that will be investigated further.