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Reason: Under embargo until November 2021. After this date a copy can be supplied under Section 51(2) of the Australian Copyright Act 1968 by submitting a document delivery request through your library
DETERMINING THE FUNCTION OF SCUBE AND ASPH IN ZEBRAFISH MYOTOME DEVELOPMENT
thesis
posted on 2018-11-07, 00:48 authored by QUOC DUY TRANHedgehog signalling plays important roles in development. To be able to function at distant tissues, Hedgehog protein must be secreted from its producing cells with the assistance of some proteins. Scube2 is one of the most well-known factors involved in Hedgehog secretion. My project investigated Scube protein family’s function in Hedgehog signalling and in development in zebrafish. My data suggests that the other Scube proteins have a minor effect on Hedgehog signalling, but they can enhance the phenotype of the scube2 mutant. Asph, an enzyme binding to Scube was also investigated. My data suggests that Asph could function in muscle development.