Cancer cell line genetic dependencies estimated using the DEMETER2 model. DEMETER2 is applied to three large-scale RNAi screening datasets: the Broad Institute Project Achilles, Novartis Project DRIVE, and the Marcotte et al. breast cell line dataset. The model is also applied to generate a combined dataset of gene dependencies covering a total of 713 unique cancer cell lines. For more information visit https://depmap.org/R2-D2/.
Visit the Cancer Dependency Map portal at https://depmap.org to explore related datasets. Email questions to depmap@broadinstitute.org
This dataset includes gene dependencies estimated using the DEMETER2 model, the raw input datasets used to fit the models, as well as associated metadata. See Readme file for more details about the dataset contents and version history.