DABCO-catalyzed synthesis of 3-substituted-3-hydroxyindolin-2-ones in aqueous media

Tiwari, Keshri Nath; Bora, Darshana; Chauhan, Garima; Yadav, Deepika; Sharma, Kavita; Thakur, Ashima; Singh, Lachhman; Tripathi, Vishwadeep

doi:10.6084/m9.figshare.3112951.v2

lsyc_a_1160411_sm6035.pdf (1.17 MB)

DABCO-catalyzed synthesis of 3-substituted-3-hydroxyindolin-2-ones in aqueous media

Version 2 2016-04-29, 13:17

Version 1 2016-03-11, 17:37

journal contribution

posted on 2016-04-29, 13:17 authored by Keshri Nath Tiwari, Darshana Bora, Garima Chauhan, Deepika Yadav, Kavita Sharma, Ashima Thakur, Lachhman Singh, Vishwadeep Tripathi

An efficient and greener protocol for easy access to 3-susbstituted-3-hydroxy-2-oxindoles by the reaction with various substituted isatins and acetophenones is described. This protocol is widely applicable for a variety of isatins and acetophenones using water as a reaction media and 1,4-diazabicyclo[2.2.2]octane (DABCO) as catalyst with shorter reaction time and good to excellent yield of products.