figshare
Browse
gnpl_a_889133_sm5411.docx (2.19 MB)

Cytotoxic activity of two natural sesquiterpene lactones, isobutyroylplenolin and arnicolide D, on human colon cancer cell line HT-29

Download (0 kB)
Version 2 2014-05-09, 09:16
Version 1 2014-05-09, 09:16
journal contribution
posted on 2014-05-09, 09:16 authored by Xuedan Huang, Yurika Awano, Eri Maeda, Yoshihisa Asada, Hiroaki Takemoto, Takashi Watanabe, Akiko Kojima-Yuasa, Yoshinori Kobayashi

In this study, we found that two sesquiterpene lactones, isobutyroylplenolin and arnicolide D, from Centipeda minima L. (Compositae) exerted stronger cytotoxic activity than cisplatin on the human colon carcinoma HT-29 cell line. Furthermore, the cytotoxicity of these two compounds on normal cells was weaker than that of cisplatin. Treatment with isobutyroylplenolin and arnicolide D increased the levels of intracellular reactive oxygen species and decreased the levels of nuclear factor-κB protein, resulting in cell cycle arrest in G1 phase and apoptosis. We also discuss the difference in structure and activity between these two compounds.

History

Usage metrics

    Natural Product Research

    Categories

    Licence

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC