Cytotoxic Polyisoprenyl Benzophenonoids from <i>Garcinia subelliptica</i>
2010-04-23T00:00:00Z (GMT) by
Six new polyisoprenyl benzophenonoids, (±)-garcinialiptone A (<b>1</b>, <b>2</b>), garcinialiptone B (<b>3</b>), (−)-cycloxanthochymol (<b>4</b>), garcinialiptone C (<b>5</b>), and garcinialiptone D (<b>6</b>), along with three known compounds, xanthochymol (<b>7</b>), isoxanthochymol (<b>8</b>), and cycloxanthochymol (<b>9</b>), were isolated from the fruits of <i>Garcinia subelliptica</i>. The structures of <b>1</b>−<b>6</b> were elucidated by spectroscopic analysis. Biological evaluation showed that all compounds <b>1</b>−<b>9</b> exhibited cytotoxic activity against a small panel of human tumor cell lines (A549, DU145, KB, vincristine-resistant KB).