Cytokine relationship with potential inflammatory effects in KD.

<p>Schematic diagram of the possible relationships existing between a number of cytokines and growth factors identified as dysregulated in KD microdissected epidermis and dermis in our microarray data. This figure should be correlated with <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0172955#pone.0172955.t002" target="_blank">Table 2</a> where the direction and fold change for each of these molecules can be found for each site within keloid epidermis and dermis. AP-1, activating protein 1; IL, interleukin; INF, interferon; JAK, janus kinase; MMP, matrix metalloproteinase; NFκB, nuclear factor kappa B; ROR, retinoic acid-related orphan receptor c; STAT, signal transducer and activator of transcription; TGFβ, transforming growth factor beta; TNF, tumour necrosis factor.</p>