Cytokine and chemokine levels in plasma and CVL from 4 ZIKV-infected female RM.

The top row is plots of the vRNA levels in plasma and CVL samples for each RM. The middle row is plots of the cytokine and CC levels in plasma samples. The bottom row is plots of the cytokine and CC levels in paired CVL samples. Each column is data from one animal. The x-axis on every graph indicates the day of sampling relative to the day of transmission designated Day 0. The vertical dashed lines indicate the timing of peak plasma vRNA levels. The shaded vertical boxes indicate the days menstrual blood was detected by visual inspection, with the first day of bleeding designated Day 1 of the menstrual cycle. The concentrations of the analytes in bold face and with larger symbols varied from baseline by about 10-fold after infection.