np6b00951_si_001.pdf (713.14 kB)
Curcumin Acrylation for Biological and Environmental Applications
journal contribution
posted on 2017-06-29, 17:52 authored by Vinod S. Patil, Angela M. Gutierrez, Manjula Sunkara, Andrew J. Morris, J. Zach Hilt, Douglass S. Kalika, Thomas D. DziublaCurcumin has recently gained interest
for use in drug delivery, chemical sensing, and environmental applications.
As a result, the development of synthesis strategies for the incorporation
of curcumin into novel materials has become a priority. One such strategy,
curcumin acrylation, involves the introduction of acrylate functional
groups to the curcumin scaffold, with the potential generation of
mono-, di-, and triacrylate curcumin species. The relative populations
of these species in the resulting multiacrylate mixture can be controlled
by the ratio of curcumin to acryloyl chloride in the initial reaction
formulation. Characterization of the acrylation reaction and the resulting
curcumin multiacrylate product is essential for the effective preparation
of new curcumin-containing materials. In this work, a synthesis method
for curcumin acrylation is presented and the resulting curcumin multiacrylate
product is characterized via various techniques, i.e., HPLC, LCMS,
and NMR, as a basis to establish the relationship between synthesis
conditions and the extent of acrylation that is achieved.