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CuH-Catalyzed Asymmetric Intramolecular Reductive Coupling of Allenes to Enones
journal contribution
posted on 2017-12-15, 19:19 authored by Yun-Xuan Tan, Xiao-Qi Tang, Ping Liu, De-Shen Kong, Ya-Li Chen, Ping Tian, Guo-Qiang LinThe
CuH-catalyzed asymmetric intramolecular reductive coupling
of allenes to enones is successfully realized, providing cis-hydrobenzofurans with promising yields and excellent enantioselectivities.
Such brilliant enantioselectivities are partially contributed by CuH-catalyzed
favorable kinetic resolution of the cyclization products. This protocol
tolerates a broad range of functional groups, allowing for further
construction of tricyclic and bridged-ring structures. Moreover, the meta-chiral functionalization of 4-substituted phenol and
asymmetric dearomatization modification of phenol-contained bioactive
molecules are also described.
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citricyclichydrobenzofuranchiral functionalizationCuH-catalyzedAllenemeta4-intramolecular reductivealleneSuchEnoneenantioselectivitiebridged-ring structuresconstructiondearomatization modificationcyclization productsenoneyieldphenol-contained bioactive moleculesCuH-Catalyzed Asymmetric Intramolecular Reductive
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