Cost-effectiveness analysis of therapeutic options for chronic hepatitis C genotype 3 infected patients

Background: This study provides a cost-effectiveness analysis of therapeutic strategies for chronic hepatitis C genotype 3 infected patients in Spain.

Methods: A Markov model was designed to simulate the progression in a cohort of patients aged 50 years over a lifetime horizon.

Results: Sofosbuvir (SOF) plus peginterferon and ribavirin for 12 weeks was a cost-effective option when compared to standard of care (SoC) in the treatment of both ‘moderate fibrosis’ and ‘cirrhotic’ patients. Incremental cost-effectiveness ratios were €35,276/QALY and €18,374/QALY respectively. ICERs for SOF plus daclatasvir (DCV) regimens versus SoC were over the threshold limit considered, at €56,178/QALY and €77,378/QALY for ‘moderate fibrosis’ and ‘cirrhotic’ patients respectively.

Conclusion: Addition of SOF to IFN-based regimens for genotype 3 was cost-effective for both ‘moderate fibrosis’ and ‘cirrhotic’ patients. IFN-free options including SOF and DCV association required price reductions lower than the list prices to be considered cost-effective.