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Correlation between SIV-specific IgG titers and Tfh cells.

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posted on 2015-12-07, 21:35 authored by Félicien Moukambi, Henintsoa Rabezanahary, Vasco Rodrigues, Gina Racine, Lynda Robitaille, Bernard Krust, Guadalupe Andreani, Calayselvy Soundaramourty, Ricardo Silvestre, Mireille Laforge, Jérôme Estaquier

(A) Histogram shows the titer of SIV-specific IgG antibodies in the serum of SIV-infected RMs at the indicated time. At day>180, open circles represent fast progressor RMs PB023 and PB028; and full diamonds represent slow progressor RMs PB013 and PB044. (B) Dot-plots show the correlation between the titer of SIV-specific IgG antibodies and the percentage as well the number of Tfh cells in LNs and spleen of RMs. (C) Dot-plots show the correlation between the titer of SIV-specific IgG antibodies and the number of B cell subsets in LN and the spleen. Spearman analysis was used for correlations. The r and p values are indicated in the figures.

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    PLOS Pathogens

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    SIVRMSplenic Tfh CellsTfh cellsrepressors KLF 2CD 4 T lymphocytesB cell activationfuture vaccine strategiesDNAsplenic Tfh cellsmemory B cellsHIVLNmemory B cell subsets

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