Copper(I) 3-Methylsalicylate Mediates the Chan–Lam N-Arylation of Heterocycles

2014-12-08T20:01:56Z (GMT) by Abdelbasset A. Farahat David W. Boykin

Copper(I) 3-methylsalicylate (CuMeSal) mediates N-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan–Lam coupling) under moderate reaction conditions (K2CO3, methanol, 65 °C, in air, 3–5 h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of N-heterocycles were allowed to react and gave N-arylation products in reasonable yields, which demonstrate the utility of this catalyst.