figshare
Browse
lsyc_a_961196_sm6673.pdf (107.77 kB)

Copper(I) 3-Methylsalicylate Mediates the Chan–Lam N-Arylation of Heterocycles

Download (0 kB)
Version 3 2014-12-08, 20:01
Version 2 2014-12-08, 20:01
Version 1 2014-12-08, 20:01
journal contribution
posted on 2014-12-08, 20:01 authored by Abdelbasset A. Farahat, David W. Boykin

Copper(I) 3-methylsalicylate (CuMeSal) mediates N-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan–Lam coupling) under moderate reaction conditions (K2CO3, methanol, 65 °C, in air, 3–5 h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of N-heterocycles were allowed to react and gave N-arylation products in reasonable yields, which demonstrate the utility of this catalyst.

History