Copper(I) 3-Methylsalicylate Mediates the Chan–Lam <i>N</i>-Arylation of Heterocycles

2014-12-08T20:01:56Z (GMT) by Abdelbasset A. Farahat David W. Boykin
<div><p></p><p>Copper(I) 3-methylsalicylate (CuMeSal) mediates <i>N</i>-arylation reactions between aryl boronic acids and aromatic heterocycles (Chan–Lam coupling) under moderate reaction conditions (K<sub>2</sub>CO<sub>3</sub>, methanol, 65 °C, in air, 3–5 h). Both electron-rich and electron-deficient aryl boronic acids and a diverse set of <i>N</i>-heterocycles were allowed to react and gave <i>N</i>-arylation products in reasonable yields, which demonstrate the utility of this catalyst.</p> </div>