Copper(II)-Catalyzed Synthesis of Benzo[<i>f</i>]pyrido[1,2-<i>a</i>]indole-6,11-dione Derivatives via Naphthoquinone Difunctionalization Reaction

2012-01-20T00:00:00Z (GMT) by Yun Liu Jin-Wei Sun
Benzo­[<i>f</i>]­pyrido­[1,2-<i>a</i>]­indole-6,11-diones have been synthesized in high yields by copper­(II)-catalyzed three-component reactions of acyl bromide, 1,4-naphthoquinone, and pyridine (or isoquinoline) via sp<sup>2</sup>–C–H difunctionalization of naphthoquinone followed by intramolecular cyclization and oxidative aromatization. In an attempt to expand the reaction scope and to help clarify the reaction mechanism, 1,3-dicarbonyl compounds are used in place of acyl bromides to take part in this reaction, and the benzo­[<i>f</i>]­pyrido­[1,2-<i>a</i>]­indole-6,11-diones derivatives are also obtained in excellent yields.