Copper-Catalyzed Intermolecular Reductive Radical Difluoroalkylation–Thiolation of Aryl Alkenes
2018-08-09T18:24:01Z (GMT) by
A novel radical-involved alkene difunctionalization catalyzed by the copper/B<sub>2</sub>pin<sub>2</sub> system has been developed, leading to the difluoroalkylation–thiolation of aryl alkenes. The use of B<sub>2</sub>pin<sub>2</sub> as an organic reductant enables the simultaneous installation of a C(sp<sup>3</sup>)–C(F<sub>2</sub>R) bond and a C(sp<sup>3</sup>)–S(R) bond across the CC bond of aryl alkenes by utilizing two electrophilic reactants. The reaction exhibits broad substrate scope, excellent diastereoselectivity, and moderate to good yields. Moreover, the reaction can be conducted on a gram scale with good yield achieved.