jo6b01776_si_001.pdf (12.9 MB)
Copper-Catalyzed Addition of H–P(O) Bonds to Arynes
journal contribution
posted on 2016-09-08, 00:00 authored by Qian Chen, Xinxing Yan, Chunxiao Wen, Jiekun Zeng, Yulin Huang, Xingguo Liu, Kun ZhangAn
efficient P-arylation of secondary phosphine oxides has been
achieved through the ligand-free copper-catalyzed addition of H–P(O)
bonds to in situ generated arynes at room temperature.
This transformation provides a straightforward route to the formation
of the aryl–P bond with wide functional group compatibility,
which produces arylphosphine oxides in up to 99% yield.