Conversion of Oxazolidinediones
to Isoindoloisoquinolinones
via Intramolecular Friedel–Crafts Reaction

Min, Ji-Young; Kim, Guncheol

doi:10.1021/jo402345q.s001

jo402345q_si_001.pdf (4.79 MB)

Conversion of Oxazolidinediones to Isoindoloisoquinolinones via Intramolecular Friedel–Crafts Reaction

journal contribution

posted on 2014-02-07, 00:00 authored by Ji-Young Min, Guncheol Kim

Treatment of oxazolidinediones with TiCl₄ in CH₂Cl₂ resulted in conversion to isoindoloisoquinolinones via intramolecular Friedel–Crafts reaction with extrusion of CO₂ in the transformation. The alkaloid nuevamine has been synthesized under these conditions in a regiospecific manner.