Conversion of Oxazolidinediones to Isoindoloisoquinolinones via Intramolecular Friedel–Crafts Reaction

2014-02-07T00:00:00Z (GMT) by Ji-Young Min Guncheol Kim
Treatment of oxazolidinediones with TiCl<sub>4</sub> in CH<sub>2</sub>Cl<sub>2</sub> resulted in conversion to isoindoloisoquinolinones via intramolecular Friedel–Crafts reaction with extrusion of CO<sub>2</sub> in the transformation. The alkaloid nuevamine has been synthesized under these conditions in a regiospecific manner.