Convenient synthesis of α-diarylmethylphosphonates by HOTf catalyzed Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates

Chen, Long; Zou, Yun-Xiang; Fang, Xin-Yue; Yin, Xu

doi:10.6084/m9.figshare.5521981.v3

gpss_a_1393424_sm9869.docx (4.42 MB)

Convenient synthesis of α-diarylmethylphosphonates by HOTf catalyzed Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates

Version 3 2018-02-20, 18:17

Version 2 2017-11-13, 19:08

Version 1 2017-10-20, 20:45

journal contribution

posted on 2018-02-20, 18:17 authored by Long Chen, Yun-Xiang Zou, Xin-Yue Fang, Xu Yin

We report a convenient catalytic Friedel-Crafts arylation of α-aryl α-hydroxyphosphonates with various (hetero)aromatic compounds. HOTf (trifluoromethanesulfonic acid) is identified to be the best Brønsted acid catalyst, and the desired α-diarylmethylphosphonates were obtained in up to 41–95% yield.