Controversies in Atypical (Dysplastic) Melanocytic Nevi: Grading and Progression

2012-12-12T20:42:52Z (GMT) by Salvador J. Diaz-Cano E Husain
<p>- High-grade intraepidermal melanocytic lesions are mainly driven by p53 over-expression, which is dissociated from cyclin-dependent kinase inhibitors (p21WAF1 and p27Kip1) in melanoma in-situ.<br>- Invasion in malignant melanomas seems to be independent of p53 expression</p>
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