Contribution of the gH/gL-Eph interaction to RRV infection is cell type-specific.

<p><b>A-B</b> Comparative infection on LEC <b>(A)</b> or HUVEC <b>(B)</b> and RF by RRV wt, RRV gH-AELAAN, and RRV ΔgL. RF and LEC or HUVEC were infected with the same inocula of the respective virus stock, and the percentage of reporter gene-positive cells as determined by flow cytometry for each dilution was plotted. <b>C</b> Micrograph of RF and LEC infected with the same respective inocula of wt and Eph-binding-negative RRV gH-AELAAN. <b>D-E</b> Comparative infection on LEC <b>(D)</b> or HUVEC <b>(E)</b> and RF by RRV wt, RRV gH-AELAAN, and RRV ΔgL as in A based on mean fluorescence intensity (MFI) as determined by flow cytometry. ***: p-value < 0.001.</p>