cg300763t_si_004.cif (18.68 kB)
Continuous Co-Crystallization As a Separation Technology: The Study of 1:2 Co-Crystals of Phenazine–Vanillin
dataset
posted on 2012-12-05, 00:00 authored by Tu Lee, Hsin Rong Chen, Hong Yu Lin, Hung Lin LeeThe selective removal of vanillin in bioconversion by
forming 1:2
co-crystals of phenazine–vanillin may serve as a new technology.
Initial solvent screening experiments of vanillin, phenazine, and
the co-crystals show that co-crystallization of phenazine and vanillin
can be formed in toluene and, later, regenerated in acetone as Form
α phenazine and vanillin solution. Co-crystallization is successfully
carried out in both continuous and batch modes with no agitation and
with stirring. However, it is found that the efficient heat transfer
due to the instant drop of bulk solution temperature to 25 °C
in continuous co-crystallization at 90 mL/min gives the advantages
of a rapid nucleation rate, B0, of 2.8
× 104 ± 4 × 103 no/l·s as
determined by the mixed suspension, mixed product removal (MSMPR)
formalism for the population balance, a wider and flatter size distribution
of 18 wt % for particle sizes of >75 to >250 μm and about
12
wt % of >300 to >500 μm by sieve analysis, and a high
yield
of 51.2 ± 0.7 wt % in comparing with the ones of 34.9 ±
0.4 wt % from batch operation with no agitation and 57.7 ± 8.1
wt % from batch mode with stirring. The wider size distribution of
particle sizes gives a better filterability of the wet cake and flowability
of the dried co-crystals.