ol9b01633_si_001.pdf (7.11 MB)
Construction of Chiral 1,3-Diamines through Rhodium-Catalyzed Asymmetric Arylation of Cyclic N‑Sulfonyl Imines
journal contribution
posted on 2019-06-19, 19:14 authored by Chun-Yan Wu, Ming-Hua XuA rhodium/sulfur–olefin
complex catalyzed asymmetric 1,2-addition
of arylboronic acids to six-membered 1,2,6-thiadiazinane 1,1-dioxide-type
cyclic imines to access highly optically active sulfamides (95–99%
ee) has been developed. By taking advantage of the simple functional
group transformations, an interesting array of valuable chiral 1,3-diamines
with different substitution patterns can be readily obtained in a
highly enantioenriched manner.