jo052656m_si_001.cif (14.13 kB)
Computationally Guided Organometallic Chemistry: Preparation of the Heptacyclic Pyrazine Core of Ritterazine N
dataset
posted on 2006-03-31, 00:00 authored by Douglass F. Taber, Karen V. TaluskieDiels−Alder cycloaddition of 10 followed by Wittig homologation and intramolecular diene cyclozirconation of the resulting triene under equilibrating conditions led to the tricyclic 6−6−5 ketone 5 with
high diastereocontrol. The derived α-azido ketone 16 cyclized efficiently to the heptacyclic pyrazine
core of ritterazine N.